Aspect oriented service composition for telecommunication applications

This PhD dissertation investigates how to overcome the negative effects of cross cutting concerns in the development of composite service applications. It proposes a combination of dynamic aspect oriented programming with a rules driven service composition mechanism. This combination allows very flexible utilization of aspects based on run-time data. The thesis contributes a join-point model and it integrates techniques for weaving and advice definition into the underlying composition language and execution engine. A particular focus of the thesis is telecommunication applications with their unique model for utilizing heterogeneous constituent services and their severe real-time requirements. Next to its primary use for modular implementation and flexible deployment of concerns in telecommunication applications, the dissertation discusses AOP as a feature for automated management and customization of service applications. The verification of the proposed solution contributes a detailed assessment of run-time performance, including a theoretical model of the AOP implementation. It allows predicting the performance of various alternative solutions. The proposed solution for combined AOP and service composition provides properties, which directly address challenges in pervasive computing and the Internet of things. Thus, this dissertation advances beyond the telecommunication domain with results applicable to various highly relevant technical developments

MiRNA expression patterns predict survival in glioblastoma

<p>Abstract</p> <p>Background</p> <p>In order to define new prognostic subgroups in patients with glioblastoma a miRNA screen (> 1000 miRNAs) from paraffin tissues followed by a bio-mathematical analysis was performed.</p> <p>Methods</p> <p>35 glioblastoma patients treated between 7/2005 - 8/2008 at a single institution with surgery and postoperative radio(chemo)therapy were included in this retrospective analysis. For microarray analysis the febit biochip "Geniom^®Biochip MPEA homo-sapiens" was used. Total RNA was isolated from FFPE tissue sections and 1100 different miRNAs were analyzed.</p> <p>Results</p> <p>It was possible to define a distinct miRNA expression pattern allowing for a separation of distinct prognostic subgroups. The defined miRNA pattern was significantly associated with early death versus long-term survival (split at 450 days) (p = 0.01). The pattern and the prognostic power were both independent of the MGMT status.</p> <p>Conclusions</p> <p>At present, this is the first dataset defining a prognostic role of miRNA expression patterns in patients with glioblastoma. Having defined such a pattern, a prospective validation of this observation is required.</p

Aspect oriented service composition for telecommunication applications

This PhD dissertation investigates how to overcome the negative effects of cross cutting concerns in the development of composite service applications. It proposes a combination of dynamic aspect oriented programming with a rules driven service composition mechanism. This combination allows very flexible utilization of aspects based on run-time data. The thesis contributes a join-point model and it integrates techniques for weaving and advice definition into the underlying composition language and execution engine. A particular focus of the thesis is telecommunication applications with their unique model for utilizing heterogeneous constituent services and their severe real-time requirements. Next to its primary use for modular implementation and flexible deployment of concerns in telecommunication applications, the dissertation discusses AOP as a feature for automated management and customization of service applications. The verification of the proposed solution contributes a detailed assessment of run-time performance, including a theoretical model of the AOP implementation. It allows predicting the performance of various alternative solutions. The proposed solution for combined AOP and service composition provides properties, which directly address challenges in pervasive computing and the Internet of things. Thus, this dissertation advances beyond the telecommunication domain with results applicable to various highly relevant technical developments